Ogerin 是选择性GPR68正向别构调节剂(pEC50:6.83)。它能够抑制小鼠对恐惧记忆的回忆。它对 A2A受体具有适中的拮抗作用(Ki:220 nM)。对 5-HT2B受体的拮抗作用较弱(Ki:736 nM)。

Ogerin is a selective GPR68 positive allosteric modulator (pEC50: 6.83). Ogerin blocks recall in fear conditioning in mice. Ogerin displays inverse agonist and antagonist activity (Ki, 220 nM) at A2A receptor and weak antagonist activity (Ki, 736 nM) at 5-HT2B receptor.

1309198-71-7

C17H17N5O

307.35

DMSO:250 mg/mL (813.40 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years