Hoechst 34580 是细胞渗透性荧光染料，可用于 DNA 和核染色。

Hoechst 34580, a cell-permeable fluorescent dye, is used for staining DNA and nuclei.

Hoechst 34580 is a good candidate for treating Alzheimer's disease by inhibiting Aβ formation. 50 μM Aβ42 solutions co-incubated with 100, 25, 12.5, 3.125, 0.78, and 0.1, 0.01 μM Hoechst 34580 at 37 °C for 70 h. Hoechst 34580 can inhibit the aggregation of Aβ42 in a dose-dependent manner. The IC50 is obtained by measuring the concentration of Hoechst 34580 while maintaining the Aβ42 concentration which gave 0.86±0.05 μM for Hoechst 34580.

23555-00-2

C27H29N7

451.57

HOE 34580

DMSO:47 mg/mL (104.08 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years