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Propargyl-PEG3-CH2COOH
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Propargyl-PEG3-CH2COOH图片
CAS NO:1694731-93-5
包装与价格:
包装价格(元)
50mg电议
100mg电议

产品介绍
Propargyl-PEG3-CH2COOH 是一种 PROTAC linker,属于 PEG 类。Propargyl-PEG3-CH2COOH 可用于合成一系列 PROTAC 分子。
Cas No.1694731-93-5
分子式C11H18O6
分子量246.26
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Propargyl-PEG3-CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[1]. Wurz RP, et al. A "Click Chemistry Platform" for the Rapid Synthesis of Bispecific Molecules for Inducing ProteinDegradation. J Med Chem. 2018 Jan 25;61(2):453-461.