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Amino-PEG11-amine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Amino-PEG11-amine图片
CAS NO:479200-82-3
包装与价格:
包装价格(元)
50mg电议
100mg电议

产品介绍
Amino-PEG11-amine 是基于 PEG (12 个单元) 的PROTAC linker,可用于链接基于 DES设计的单体配体,为制备更具选择性和更高活性的雌激素受体拮抗剂用于提供新的方向。
Cas No.479200-82-3
别名氨基-十二聚乙二醇-氨基
分子式C24H52N2O11
分子量544.68
储存条件-20°C, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Amino-PEG11-amine, a PEG-based (12 units) PROTAC linker used to combine two mono diethylstilbestrol (DES)-based ligands, provides an alternative strategy for preparing more selective and active ER antagonists for endocrine therapy of breast cancer[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[1]. Shan M, et al. Nonsteroidal bivalent estrogen ligands: an application of the bivalent concept to the estrogen receptor. ACS Chem Biol. 2013 Apr 19;8(4):707-15.