DAMGO 是一种阿片受体激动剂，Kd值为 3.46 nM。它能够影响啮齿动物的运动活动，可作为镇痛剂。

DAMGO is an opioid receptor agonist with the ability to affect the locomotive activity in rodents. Possible analgesic agent due to μ-opiod receptor interaction.

(1) DAMGO inhibits GABAergic inputs in VTA-DA neurons at presynaptic sites; (2) effect of DAMGO on GABAergic inputs in VTA-DA neurons is inhibited by potassium channel blocker 4-aminopyridine (4-AP) and Gi protein inhibitor N-ethyl maleimide (NEM); (3) phospholipase A2 (PLA2) does not mediate the effect of DAMGO on GABAergic inputs in VTA-DA neurons, but mediates it in the periaqueductal gray (PAG); (4) multiple downstream signaling molecules of l receptors do not mediate the effect of DAMGO on GABAergic inputs in VTA-DA neurons. These results suggest that DAMGO depresses inhibitory synaptic transmission via l receptor-Gi protein-Kv channel pathway in VTA-DA neurons, but via l receptor-PLA2 pathway in PAG

78123-71-4

C26H35N5O6

513.595

RX-783006;Dagol;DAGO

DMSO:33.33 mg/mL (64.90 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years