BIBO3304 TFA 是一种可口服的、选择性的神经肽Y(NPY) Y1受体高效拮抗剂，对人和大鼠 Y1 受体均具有高亲和力，IC50分别为 0.38 和 0.72 nM。

BIBO3304 TFA is an effective, orally active, and selective neuropeptide Y (NPY) Y1 receptor antagonist (IC50:0.38 and 0.72 nM for the human and the rat Y1 receptor).

BIBO3304 TFA (15-60 μg) dose-dependently inhibits the feeding response mediated by 1 μg NPY. BIBO3304 TFA (30 μg; bilateral paraventricular nucleus injection) attenuates the hyperphagia following fasting [1]. BIBO3304 TFA (0.5?μM; p.o.) significantly increases serum insulin levels [2].

191868-14-1

C31H36F3N7O5

643.66

DMSO:100 mg/mL (155.36 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years