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1-Cbz-3-Hydroxyazetidine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
1-Cbz-3-Hydroxyazetidine图片
CAS NO:128117-22-6
包装与价格:
包装价格(元)
1 g电议
5 g电议

产品介绍
1-Cbz-3-Hydroxyazetidine 是不可降解 (non-cleavable) 的 ADC linker,用于合成抗体偶联药物 (ADCs)。1-Cbz-3-Hydroxyazetidine 也是一个基于烷基链 (alkyl chain) 的 PROTAC linker,可用于合成 PROTAC。
Cas No.128117-22-6
别名1-苄氧羰基-3-羟基氮杂环丁烷
分子式C11H13NO3
分子量207.23
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

1-Cbz-3-Hydroxyazetidine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 1-Cbz-3-Hydroxyazetidine is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337.
[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.