| CAS NO: | 1056024-94-2 |
| 包装 | 价格(元) |
| 50mg | 电议 |
| 100mg | 电议 |
| Cas No. | 1056024-94-2 |
| 别名 | 叠氮-三乙二醇-丙酸 |
| 分子式 | C9H17N3O5 |
| 分子量 | 247.25 |
| 溶解度 | DMSO : 100 mg/mL (404.45 mM; Need ultrasonic) |
| 储存条件 | -20°C, protect from light |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | N3-PEG3-CH2CH2COOH a PEG-based PROTAC linker can be used in the synthesis of BI-3663 , BI-4216 and BI-0319. Azido-PEG3-acid is also a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. [1]. Popow J, et al. Highly Selective PTK2 Proteolysis Targeting Chimeras to Probe Focal Adhesion Kinase Scaffolding Functions. J Med Chem. 2019 Mar 14;62(5):2508-2520. |
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