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m-PEG4-CH2COOH
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
m-PEG4-CH2COOH图片
CAS NO:16024-66-1
包装与价格:
包装价格(元)
50mg电议
100mg电议

产品介绍
m-PEG4-CH2COOH 是一种基于 PEG 的 PROTAC linker,用于 PROTAC 合成。
Cas No.16024-66-1
别名甲基-四聚乙二醇-乙酸
分子式C11H22O7
分子量266.29
溶解度DMSO : 100 mg/mL (375.53 mM; Need ultrasonic)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

m-PEG4-CH2COOH is a PEG-based based PROTAC linker can be used in the synthesis of PROTACs.

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[1]. TaoDeng, et al. Monodisperse oligoethylene glycols modified Propofol prodrugs. Bioorganic & Medicinal Chemistry Letters.