Galanin Receptor Ligand M35 TFA(142846-71-7 free base) 是一种高亲和力配体和甘丙肽受体拮抗剂 (Kd=0.1 nM)。

Galanin Receptor Ligand M35 TFA is a high-affinity ligand and antagonist of galanin receptor (Kd=0.1 nM).

Galanin Receptor Ligand M35 TFA has a dual effect on the galanin mediated inhibition of Forskolin stimulated cyclic AMP production in Rin m 5F cells. Co-applied with galanin (10 nM), Galanin Receptor Ligand M35 TFA at low concentrations (1 nM) is able to reverse the inhibitory effect of galanin. But when present at higher concentrations (15 and 30 nM), Galanin Receptor Ligand M35 TFA acts as a galanin receptor agonist, inhibiting the forskolin-stimulated production of cAMP. These agonist-like effects of galanin and Galanin Receptor Ligand M35 TFA are not additive, thus the mixed agonist/antagonist properties arise from the chimeric nature of Galanin Receptor Ligand M35 TFA acting solely at galanin receptors[1].

Galanin Receptor Ligand M35 TFA (6 nM/10 μL; i.c.v.) improves the ability of the male Sprague-Dnwley rats to acquire the swim maze task that shortened the escape latency, reduced the number of failures to reach the platform, and shortened the path length to reach the hidden platform[3].

TP1704

C109H154N27F3O28

2347.62

DMSO:10 mM
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In solvent: -80°C for 2 years