CGP71683 hydrochloride 是竞争性的神经肽受体拮抗剂，Ki值为 1.3 nM。

CGP71683 is a competitive neuropeptide Y5 receptor antagonist (Ki: 1.3 nM) and shows no obvious activity at Y1 receptor (Ki >4000 nM) and Y2 receptor (Ki: 200 nM) in cell membranes.

CGP71683 (1-10 mg/kg, i.p.) dose-dependently decreased nocturnal and fasting-induced food intake. CGP71683A did not have an anxiogenic-like effect in the rat social interaction test. In the open-field test, carried out immediately after the elevated plus-maze test, CGP71683A inhibited horizontal and vertical activity [2].

192322-50-2

C26H30ClN5O2S

512.07

盐酸CGP71683;CGP71683A

DMSO:120 mg/mL (234.34 mM)
H2O:10 mg/mL (19.53 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years