FurazolIDOne是一种具有抗菌和抗原虫活性的硝基呋喃衍生物，抑制AML1-ETO转化细胞，IC50为12.7 μM。

Furazolidone, a nitrofuran derivative, inhibits AML1-ETO transformed cells with IC50 value of 12.7 μM. It is antibacterial and antiprotozoal activity,

Furazolidone displays potent antiproliferative properties at submicromolar concentrations and induces apoptosis in AML cell lines. Furazolidone treatment of certain AML cells induces myeloid cell differentiation by morphology and flow cytometry for CD11b expression, resulting in increased stability of tumor suppressor p53 protein in AML cells[1].

FZ accelerates its own metabolism in the chicken by induction of the activity of CPR whereas no effect is observed in the rat[2].

Leukemic cells are seeded in 96-well culture plates at a density of 1 or 2×104 viable cells/100 µl/well in triplicates and are treated for 24, 48, and 72 hours with an incremental concentration of FZD ranging from 1 µM to 50 µM. Colorimetric CellTiter 96® Aqueous One Solution Cell Proliferation assay is used to determine the cytotoxicity. The optical density at 492 nm is measured using a Multiskan Ascent® microplate photometer. IC50 values are determined by MTS assay when cells are treated with FZD for 72 hours and calculated with GraphPad Prism 5. Each experiment was in triplicate. (Only for Reference)

67-45-8

C8H7N3O5

225.16

Furoxone;呋喃唑酮

Ethanol:<1 mgml
DMSO:>10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years