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Bupropion hydrochloride
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Bupropion hydrochloride图片
CAS NO:31677-93-7
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)电议
50mg电议

产品介绍
Dopamine/norepinephrine inhibitor
Cas No.31677-93-7
别名盐酸氨非他酮; Amfebutamone hydrochloride
化学名2-(tert-butylamino)-1-(3-chlorophenyl)propan-1-one;hydrochloride
Canonical SMILESCC(C(=O)C1=CC(=CC=C1)Cl)NC(C)(C)C.Cl
分子式C13H19Cl2NO
分子量276.2
溶解度≥ 12.85mg/mL in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Bupropion hydrochloride is a dual effective inhibitor of norepinephrine and dopamine neurotransmitter with the IC50 values of 6.5 ± 0.6μM and 3.4 ± 0.4 μM, respectively [1].

Bupropion hydrochloride is an aminoketone used as non-nicotine aid to smoking cessation. Bupropion hydrochloride is also a typical antidepressant agent that interferes with norepinephrine, serotonin, and dopamine reuptake [2]. In addition, Bupropion hydrochloride has been reported to reduce the expression of tyrosine hydroxylase, a rate-limiting enzyme in dopamine biosynthesis [3]. In vitro, it has been shown that Bupropion hydrochloride can decrease cell viability significantly in SH-SY5Y cells. Furthermore, Bupropion hydrochloride has been revealed to selectively activate an ER stress pathway. Apart from these, the result has also shown that Bupropion hydrochloride can induce cell death as a result of caspase 3 activation through the JNK and ER stress [2].

References:
[1] Dr. R. M. Ferris*, H. L. White,B. R. Cooper, R. A. Maxwell, F. L. M. Tang,O. J. Beaman and A. Russell .Some neurochemical properties of a new antidepressant, bupropion hydrochloride (Wellbutrin(TM)). Drug Development Research Volume 1, Issue 1, pages 21–35, 1981
[2] Jang EH1, Park CS, Kang JH. Bupropion, an atypical antidepressant, induces endoplasmic reticulum stress and caspase-dependent cytotoxicity in SH-SY5Y cells. Toxicology. 2011 Jul 11;285(1-2):1-7.
[3] Nestler, E.J., McMahon, A., Sabban, E.L., Tallman, J.F., Duman, R.S., 1990. Chronicantidepressant administration decreases the expression of tyrosine hydroxylase

in the rat locus coeruleus. Proc. Natl. Acad. Sci. U. S. A. 87, 7522–7526.