| CAS NO: | 40013-87-4 |
| 包装: | 1mg |
| 市场价: | 7400元 |
| Cas No. | 40013-87-4 |
| 别名 | 24,25-二羟基维生素 D3 |
| 化学名 | (6R)-6-[(1R,3aS,4E,7aR)-4-[(2Z)-2-[(5S)-5-hydroxy-2-methylidenecyclohexylidene]ethylidene]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-1-yl]-2-methylheptane-2,3-diol |
| Canonical SMILES | CC(CCC(C(C)(C)O)O)C1CCC2C1(CCCC2=CC=C3CC(CCC3=C)O)C |
| 分子式 | C27H44O3 |
| 分子量 | 416.64 |
| 溶解度 | Soluble in DMSO |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 文献引用 | |
| 产品描述 | 24, 25-dihydroxyvitamin D3 [24,25(OH)2D3] is a Vitamin D (VD [1]) analogue that can inhibit some metabolic processes. It dose-dependently inhibited the intracellular 10-mM-Ca2+-evoked Ca2+-concentration-increase in enterocytes with an EC50 of 4.9 nM [2]. Vitamin D is important in calcium homeostasis, skeleton maintenance, and skeleton development. Two successive reactions are involved in the formation of VD: first the formation of 25-hydroxyvitamin D (25OHD); and second the formation of 1α, 25-dihydroxyvitamin D [1, 25(OH) 2D], the active hormonal vitamin D [3]. Ca2+ at 10 mM typically increased [Ca2+]i to a new stable value of 264 ± 16 nM from the basal value of 203 ± 13 nM. 24R, 25(OH)2D3 at concentrations from 0.2 pM to 202 nM dose-dependently inhibited the initial [Ca2+]i increase during the first 18 s (t= 300 to 318 s) and the final [Ca2+]i increase (t= 550 to 600 s), with EC50 values of 4.9 nM and 30 nM, respectively. 24R, 25(OH)2D3 at a concentration of 20 nM obtained the maximal inhibition (approximately 60%) to the Ca2+ uptake [2]. In adult female mongrel dogs with renal insufficiency, 24,25(OH)2D3 significantly decreased ionized calcium compared with the CK, without any changes in detected total calcium. This decrease was evident during the 2nd week. 24,25-(OH)2D3 treatment for an additional 4 weeks resulted in a very small additional decrease in the ionized calcium. 24,25(OH)2D3 made calcium balance in dogs slightly positive, while the calcium balance in the CK dogs was slightly negative [4]. References: |
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