Calcitonin salmon 是一种阿米林和卡西宁受体的双激动剂,是一种钙调节激素,能够刺激骨的生成并能抑制骨吸收。
产品描述
Calcitonin salmon, a calcium regulating hormone, is used to treat osteoporosis in women who are at least 5 years past menopause.
体内活性
Oral Calcitonin salmon treatment attenuates fasting and non-fasted hyperglycaemia during the intervention period in a dose-dependent manner. At the end of the study period, oral Calcitonin salmon treatment by dose decreases diabetic hyperglycaemia by ~9 mM and reduces HbA1c levels by 1.7%. Moreover, a pronounced reduction in glucose excursions is dose-dependently observed for oral Calcitonin salmon treatment during oral glucose tolerance test. In addition, oral Calcitonin salmon treatment sustains hyperinsulinaemia and attenuates hyperglucagonaemia and hypersecretion of total glucagon-like peptide-1 predominantly in the basal state. Lastly, oral Calcitonin salmon treatment dose-dependently improves pancreatic beta-cell function and beta-cell area at study end[1].
Cas No.
47931-85-1
分子式
C145H240N44O48S2
分子量
3431.85
别名
Calcitonin salmon;鲑降钙素;Salmon calcitonin
储存和溶解度
H2O:50 mg/mL (14.57 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years