Phellopterin 是一种分离自P. trifoliata中的天然产物。它能够调节 Akt 和 PKC 通路,抑制 TNF-alpha 诱导的 VCAM-1 表达,进而减少单核细胞与内皮细胞的粘附。
产品描述
Phellopterin is a partial agonist of the central benzodiazepine receptors in vitro. Phellopterin shows a cytotoxic effect on RAW264.7 cell at the concentration from 40 to 400 μM. Phellopterin reduce TNF-alpha-induced VCAM-1 expression through regulation of the Akt and PKC pathway, which contributes to inhibit the adhesion of monocytes to endothelium.
Cas No.
2543-94-4
分子式
C17H16O5
分子量
300.31
储存和溶解度
DMSO:Soluble
Chloroform:Soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years