Acetyl-Calpastatin (184-210) (human) 是一种有效、选择性和可逆的钙蛋白酶抑制剂,对 μ-calpain 和组织蛋白酶 L 的 Ki 值分别为 0.2 nM 和 6 μM。
Cas No. | 123714-50-1 |
别名 | 乙酰钙蛋白酶抑制蛋白(184-210)(人) |
Canonical SMILES | CC[C@]([C@@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@]1([H])CCCN1C([C@](/N=C(O)/C)([H])CC(O)=O)=O)([H])CCSC)([H])CO)([H])CO)([H])[C@@](O)([H])C)([H])CC2=CC=C(O)C=C2)([H])/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N |
分子式 | C142H230N36O44S |
分子量 | 3177.65 |
溶解度 | Soluble to 5 mg/ml in Water |
储存条件 | Desiccate at -20℃ |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | Selective calpain inhibitor. Strongly inhibits calpain I (Ki= 0.2 nM) and II but does not inhibit papain, trypsin and cathepsin L (Ki= 6 μM). Increases secretion of amyoid β-protein (Aβ) 42, Aβ40 and Aβ42 ratio. |