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Acebutolol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Acebutolol图片
CAS NO:37517-30-9
包装与价格:
包装价格(元)
50mg电议
100mg电议
250mg电议
500mg电议

产品介绍
Acebutolol 是一种具有口服活性的 β1 肾上腺素受体 (β1AR) 拮抗剂。
Cas No.37517-30-9
别名醋丁洛尔;醋丁酰心安
Canonical SMILESO=C(CCC)NC1=CC=C(C(C(C)=O)=C1)OCC(CNC(C)C)O
分子式C18H28N2O4
分子量336.4
溶解度DMF: 10 mg/mL,DMSO: 5 mg/mL,Ethanol: 5 mg/mL,PBS (pH 7.2): 0.3 mg/mL
储存条件-20буC
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Acebutolol is an antagonist of β1-adrenergic receptors (β1-ARs; Ki= 125 nM).1It is selective for β1- over β2-ARs (Ki= 7,070 nM).In vivo, acebutolol decreases isoprenaline-induced tachycardia and diastolic hypotension in cats (ED50= 0.09 mg/kg for both).2Acebutolol (12.5, 25, and 50 mg/kg) inhibits ouabain-induced arrhythmias in rabbits, as well as protects against chloroform-induced ventricular fibrillation in mice (ED50= 0.067 mg/kg).3Formulations containing acebutolol have been used in the treatment of angina and irregular heartbeat.

1.Tsuchihashi, H., Nakashima, Y., Kinami, J., et al.Characteristics of 125I-iodocyanopindolol binding to β-adrenergic and serotonin-1B receptors of rat brain: Selectivity of β-adrenergic agentsJpn. J. Pharmacol.52(2)195-200(1990) 2.Basil, B., Jordan, R., Loveless, A.H., et al.β-Adrenoceptor blocking properties and cardioselectivity of M & B 17,803ABr. J. Pharmacol.48(2)198-211(1973) 3.Basil, B., Jordan, R., Loveless, A.H., et al.A comparison of the experimental anti-arrhythmic properties of acebutolol (M and B 17,803), propranolol and practololBr. J. Pharmacol.50(3)323-333(1974)