IEM 1754 2HBr 是一种选择性 AMPA/红藻氨酸受体阻滞剂，作用于 GluR1 和 GluR3，IC50 为 6 μM。

IEM 1754 2HBr is a selective AMPA/kainate receptor blockers for GluR1 and GluR3 with IC50 of 6 μM.

IEM 1754 is an adamantane derivative. IEM 1754 causes use- and voltage-dependent block of open channels of recombinant AMPA receptors. This antagonism is dependent on receptor subunit composition, channels gated by recombinant, homomeric GluR1 and GluR3 receptors exhibites a higher sensitivity to block than those gated by receptors containing edited GluR2 subunits. [1] IEM-1754 block of GluR2-containing AMPAR is enhanced by hyperpolarization in agreement with the classical single-exponential model. In contrast, the block of GluR2-lacking AMPAR is reduced by hyperpolarization. [2]

162831-31-4

C16H32Br2N2

412.254

IEM 1754 dihydrobromide

H2O:75 mg/mL (181.9 mM)
Ethanol:<1 mgml
DMSO:76 mg/mL (184.4 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years