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sn-Glycero-3-phosphocholine
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
sn-Glycero-3-phosphocholine图片
CAS NO:28319-77-9
包装:1g
市场价:450元

产品介绍
sn-Glycero-3-phosphocholine (Choline Alfoscerate) 是脑磷脂生物合成的前体，可增加神经组织中胆碱的生物利用度。
Cas No.28319-77-9
别名甘磷酸胆碱; Choline Alfoscerate; Alpha-GPC; L-α-GPC
化学名[(2R)-2,3-dihydroxypropyl] 2-(trimethylazaniumyl)ethyl phosphate
Canonical SMILESC[N+](C)(C)CCOP(=O)([O-])OCC(CO)O
分子式C8H20NO6P
分子量257.22
溶解度≥ 11.2mg/mL in Water
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

sn-Glycero-3-phosphocholine (Choline Alfoscerate) is a precursor in the biosynthesis of brain phospholipids and increases the bioavailability of choline in nervous tissue. sn-Glycero-3-phosphocholine (Choline Alfoscerate) has significant effects on cognitive function with a good safety profile and tolerability, and is effective in the treatment of Alzheimer's disease and dementia[1][2].

Treatment with sn-Glycero-3-phosphocholine (Choline Alfoscerate) (250 mg/kg; i.m.; daily for 3 weeks) after seizure can improve seizure-induced cognitive impairment[2].sn-Glycero-3-phosphocholine (Choline Alfoscerate) increases the release of acetylcholine in rat hippocampus, facilitates learning and memory in experimental animals, improves brain transduction mechanisms and decreases age-dependent structural changes occurring in rat brain areas involved in learning and memory[3].

References:
[1]. Traini E, et al. Choline alphoscerate (alpha-glyceryl-phosphoryl-choline) an old choline- containing phospholipidwith a still interesting profile as cognition enhancing agent. Curr Alzheimer Res. 2013 Dec;10(10):1070-9.
[2]. Traini E, et al. Choline alphoscerate (alpha-glyceryl-phosphoryl-choline) an old choline- containing phospholipidwith a still interesting profile as cognition enhancing agent. Curr Alzheimer Res. 2013 Dec;10(10):1070-9.
[3]. Lee SH, et al. Late treatment with choline alfoscerate (l-alpha glycerylphosphorylcholine, α-GPC) increases hippocampal neurogenesis and provides protection against seizure-induced neuronal death and cognitive impairment. Brain Res. 2017 Jan 1;1654(Pt A):66-76.