| 包装 | 价格(元) |
| 10mM (in 1mL DMSO) | 电议 |
| 50mg | 电议 |
Cell lines | Corneal epithelial cells |
Preparation method | The solubility of this compound in DMSO is >14.7 mg/mL. General tips for obtaining a higher concentration: Please warm the tube at 37 ℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below - 20 ℃ for several months. |
Reacting condition | 1, 4, 12, 24 and 48 hrs |
Applications | Compared with Bromfenac Sodium, the cellular metabolic activity of Diclofenac and Fluorometholone markedly decreased after 12-hr exposure. However, the K+ and Cl- concentrations, pH and osmolarity were similar among different treatment groups. In additioin, Bromfenac Sodium significantly promoted cell migration, as well as restored wound gap after 48-hr exposure, compared with Diclofenac and Fluorometholone. |
Animal models | A rabbit model of ocular inflammation |
Dosage form | 50 μL 0.09% |
Applications | In a rabbit model of ocular inflammation, Bromfenac Sodium almost completely inhibited lipopolysaccharide (LPS)-induced increases in fluorescein isothiocyanate (FITC)-dextran in the anterior chamber as well as the contralateral eye. In addition, Bromfenac Sodium significantly inhibited LPS-induced increases in PGE2 concentrations in the aqueous humor. |
Other notes | Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal. |
| 产品描述 | Bromfenac (sodium hydrate) is a nonsteroidal anti-inflammatory drug (NSAID), which has anti-inflammatory activity(1) Bromfenac (sodium hydrate) (1 mg/kg, i.v.) is metabolited into an unusual conjugate, bromfenac N-glucoside, in rats bile(2) Bromfenac (sodium hydrate) permeation was found to be 1.62-fold higher through ChS-CS-NPs References: |
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