您好，欢迎来到试剂仪器网！ [登录] [免费注册]
试剂仪器网
发布求购
位置：首页 > 产品库 > Fexofenadine HCl
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
Fexofenadine HCl
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Fexofenadine HCl图片
CAS NO:153439-40-8
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)电议
10mg电议
50mg电议

产品介绍
Fexofenadine (MDL-16455) hydrochloride 是一种具有口服活性的非镇静 H1 受体拮抗剂。
Cas No.153439-40-8
别名盐酸非索非那定; MDL-16455 hydrochloride; Terfenadine carboxylate hydrochloride
化学名2-[4-[1-hydroxy-4-[4-[hydroxy(diphenyl)methyl]piperidin-1-yl]butyl]phenyl]-2-methylpropanoic acid;hydrochloride
Canonical SMILESCC(C)(C1=CC=C(C=C1)C(CCCN2CCC(CC2)C(C3=CC=CC=C3)(C4=CC=CC=C4)O)O)C(=O)O.Cl
分子式C32H39NO4.HCl
分子量538.12
溶解度≥ 26.9mg/mL in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Fexofenadine hydrochloride (MDL-16455 hydrochloride), a H1R antagonist, is an anti-allergic agent used in seasonal allergic rhinitis and chronic idiopathic urticarial (person aged ≥16 years)[1].

Fexofenadine hydrochloride (MDL-16455 hydrochloride) (100 μM; 1 hour) effectively blocks phosphorylated p38 activation in histamine-induced nasal fibroblasts[2].

Fexofenadine hydrochloride (MDL-16455 hydrochloride) (5-20 mg/kg; oral daily for 3 weeks) dose-dependently suppresses eosinophilia in C57BL/6 mice infected with T. spiralis[1].

References:
[1]. Watanabe N, et al. The effects of fexofenadine on eosinophilia and systemic anaphylaxis in mice infected with Trichinella spiralis. Int Immunopharmacol. 2004 Mar;4(3):367-75.
[2]. Park IH, et al. Histamine Promotes the Release of Interleukin-6 via the H1R/p38 and NF-κB Pathways in NasalFibroblasts. Allergy Asthma Immunol Res. 2014 Nov;6(6):567-72.