IKK-3 Inhibitor 是 TBK1 和 IKKε 的双重抑制剂； IC50 分别为 93 nM 和 469 nM。
| Cas No. | 862812-98-4 |
| 化学名 | 5-(5,6-dimethoxy-1H-benzo[d]imidazol-1-yl)-3-((2-(methylsulfonyl)benzyl)oxy)thiophene-2-carbonitrile |
| Canonical SMILES | COC1=C(OC)C=C2C(N=CN2C3=CC(OCC4=CC=CC=C4S(=O)(C)=O)=C(C#N)S3)=C1 |
| 分子式 | C22H19N3O5S2 |
| 分子量 | 469.53 |
| 溶解度 | DMF: 12.5 mg/ml,DMSO: 20 mg/ml,DMSO:PBS (7.2 pH) (1:3): 0.25 mg/ml |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | An IKK-3 Inhibitor. The NF-κB/Rel transcription factors, known to be involved in the regulation of pro-inflammatory cytokines and the pathogenesis of a variety of diseases, are present in the cytosol in an inactive state, complexed with inhibitory IκB proteins. NF-κB is activated upon degradation of IκB following IKK-α and IKK-β phosphorylation. IKK-ε, a homolog of IKKα and IKK-β, can also activate NF-κB. IKK-ε is expressed predominantly in immune cells, and is thought to play a role in the immune response. It is a benzimidazole analog that selectively inhibits IKK-ε with an IC50 value of 40 nM and is essentially inactive at IKK-α and IKK-β. |
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