LY2365109 hydrochloride 是高选择性GlyT1抑制剂，抑制过表达 hGlyT1 细胞摄取谷氨酸的IC50值为 15.8 nM.

LY2365109 hydrochloride is a potent and selective GlyT1 inhibitor, with an IC50 of 15.8 nM for glycine uptake in cells over-expressing hGlyT1a.

LY2365109 hydrochloride increases seizure thresholds in mice[2].LY2365109 hydrochloride (0.3-30 mg/kg; p.o.) produces dose-dependent elevations in CSF levels of glycine[1].?

1779796-27-8

C22H28ClNO5

421.91

LY2365109盐酸盐

DMSO:30 mg/mL (71.11 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years