MCL 0020 是一种有效的选择性黑素皮质素MC4受体拮抗剂，IC50为 11.63 nM。它剂量依赖性减轻束缚应激诱发的厌食症，在体内表现出抗焦虑样活性。

Potent and selective melanocortin MC4 receptor antagonist (IC50 values are 11.63, 1115 and >10 000 nM at MC4, MC3 and MC1 receptors respectively). Significantly reverses stress-induced anorexia but has no effect on food intake in free-feeding rats. Exhibits anxiolytic-like activity in vivo.

475498-26-1

C34H39N7O4

609.731

MCL 0020

25% ethanol / water:2 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years