Doxepin hydrochloride 是一种可口服的三环抗抑郁剂，是选择性组胺受体H1拮抗剂。它也是CYP450抑制剂，抑制CYP450 2C19和CYP450 1A2。

Doxepin Hydrochloride is a dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mechanism of action is not fully understood, but it appears to block reuptake of monoaminergic neurotransmitters into presynaptic terminals. It also possesses anticholinergic activity and modulates antagonism of histamine H(1)- and H(2)-receptors.

1229-29-4

C19H22ClNO

315.84

盐酸多塞平;Aponal;Novoxapin;Doxepin HCl;Toruan

DMSO:31.6 mg/mL(100 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years