TCS-OX2-29 是高亲和力和选择性OX2R拮抗剂，IC50值为 40 nM，pKI值为 7.5。它对 OX2 的选择性比 OX1 高 250 倍以上。

TCS-OX2-29 is a potent and selective OX2 receptor antagonist (IC50: 40 nM). It displays >250-fold selectivity for OX2 over OX1.

TCS-OX2-29 shows selectivity for ion channels, and transporters (<30% inhibition at 10 μM), which includes G-protein coupled receptors associated with food intake including galanin and neuropeptide Y[1]. TCS-OX2-29 Inhibits orexin A-induced IP3 accumulation and ERK1/2 phosphorylation in CHO cells transfected with the OX2 receptor[2].

372523-75-6

C23H31N3O3

397.519

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years