Agnuside 是从黄荆中分离得到的一种天然产物，可下调炎性介质PGE2和LTB4，减少细胞因子的表达，具有抗关节炎活性。

Agnuside inhibits COX-2 (IC50: 0.026 mg/ml) but exhibits less than 10% inhibition of COX-1 at this concentration. It also inhibits 46.3, 66.8, and 82.1% of P-glycoprotein (P-gp) ATPase activity at concentrations of 5, 25, and 100 μM, respectively.

Agnuside (0.1-10 μM) induces proliferation of MCF-7 breast cancer cells, an effect that is inhibited by the estrogen receptor antagonist fulvestrant [2].

Agnuside (50 mg/kg) reduces acetic acid-induced writhing in mice indicating analgesia.3 It also suppresses production of the pro-inflammatory mediators' prostaglandin E2 (PGE2) and leukotriene B4 and the T cell-mediated cytokines IL-2, TNF-α, INF-γ, IL-4, IL-10, and IL-17 in splenocytes and arthritic paw tissue from arthritic adrenalectomized rats.4

11027-63-7

C22H26O11

466.439

牡荆油;chasteberry oil;穗花牡荆苷

DMSO:10 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years