Trifluoperazine dihydrochloride 是一种抗精神病药物，靶向中枢多巴胺受体。它是流感病毒形态发生的可逆抑制剂，是NUPR1抑制剂，具有抗癌活性。它是钙调蛋白抑制剂，还可抑制 P-糖蛋白，可研究精神分裂症。

Trifluoperazine Dihydrochloride is a potent dopamine D2 receptor inhibitor used as an antipsychotic and an antiemetic.

Trifluoperazine binds to α1A- and α1B-adrenoceptor with Ki value of 27.6 nM and 19.2 nM, respectively, with α1B/α1A ratio of 0.7. [2] Trifluoperazine inhibits Mycobacterium tuberculosis (Mtb) with MICs of 7.6 μg/mL. [3] Trifluoperazine (< 14.78 mM) suppresses the activities of the mouse splenic NK cell cytotoxicity and the effector-target cell conjugation in a dose dependent manner. Trifluoperazine suppresses interferon-alpha or interleukin-2 induced augmentation of the cytolytic activity of NK cells. [4] Trifluoperazine inhibits the gene expression of voltage-dependent potassium channel Kv2.1 from human brain (hKv2.1). [5]

Trifluoperazine dose dependently decreases avoidance responses and increases response failures in rats where behavior is maintained under a discrete-trial avoidance. [6]

440-17-5

C21H26Cl2F3N3S

480.42

Urinox;Trifluoperazine 2HCl;盐酸三氟拉嗪;SKF5019

H2O:88 mg/mL (183.2 mM)
DMSO:82 mg/mL (170.7 mM)
Ethanol:89 mg/mL (185.3 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years