Polygalacic acid 是一种从远志Polygala tenuifolia Willd根中分离出来的三萜，可抑制MMP表达。它对认知障碍有显著的神经保护作用，PA 通过抑制乙酰胆碱酯酶活性，增加胆碱乙酰转移酶活性，提高海马和额皮质中的乙酰胆碱水平来提高胆碱能系统反应性。 它可以用于骨关节炎相关研究。

Polygalacic acid(PA) significantly improves cholinergic system reactivity, as indicated by decreased acetylcholinesterase (AChE) activity, increases choline acetyltransferase (ChAT) activity, and elevates levels of acetylcholine (ACh) in the hippocampus and frontal cortex, PA also significantly ameliorates neuroinflammation and oxidative stress in mice; suggest that PA might exert a significant neuroprotective effect on cognitive impairment, driven in part by the modulation of cholinergic activity and neuroinflammation. Polygalacic acid shows significant postingestive effects on Spodoptera littoralis larvae.

22338-71-2

C30H48O6

504.708

Virgaureagenin G;毛果一枝黄花皂苷元G;远志酸

DMSO:91 mg/mL(180.3 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years