SHP099 free base 是一种选择性的，有效的，有口服活性的SHP2抑制剂，IC50=70 nM。

SHP099 free base is an effective, selective, orally bioavailable, and efficacious SHP2 inhibitor (IC50 =0.07 μM and p-ERK modulation in cells IC50 = 0.250 μM). SHP099 shows dose-dependent pathway inhibition and antitumor activity in xenograft models.

1801747-42-1

C16H19Cl2N5

352.26

SHP 099;SHP-099;SHP099 free base

DMSO:Soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years