ShepHERdin 79-87 acetate 是 HSP90 和 Survivin 之间复合物的拟肽拮抗剂，Survivin 是肿瘤细胞活力的另一个关键调节剂。

Shepherdin 79-87 acetate is a peptidomimetic antagonist of the complex between Hsp90 and survivin, another key regulator of tumor cell viability.

When added to prostate carcinoma (PC3, DU145) or HeLa cells, shepherdin caused concentration-dependent and complete loss of cell viability[1].

Shepherdin-RV (50 mg/kg, i.p., daily) nearly completely ablated tumor growth in immunocompromised mice prostating carcinoma PC3 cells. In a breast cancer xenograft model that employs MCF-7 cells adapted in vivo, injection of Shepherdin-RV resulted in exponentially growing tumors independently of estrogen supplementation, which was unaffected by saline administration. Shepherdin-RV (50 mg/kg i.p. daily) uniformly inhibited the growth of these more aggressive tumors (p = 0.01) throughout a 23-day or 11-day treatment regimen. Shepherdin treatment resulted in nearly complete loss of Akt levels in tumor cells and severely attenuated expression of survivin[1].

T12896L

C43H68N12O14S

1009.14

Shepherdin 79-87 acetate (861224-28-4 free base)

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years