AST 487 是RET激酶抑制剂 (IC50:880 nM)，能够抑制 RET 自磷酸化，及下游效应器激活，也抑制FLT-3 (IC50:520 nM)。

AST 487 is a RET kinase inhibitor, inhibiting RET autophosphorylation and activation of downstream effectors. It also can inhibit Flt-3.

630124-46-8

C26H30F3N7O2

529.568

NVP-AST 487

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years