SelperCATinib 是RET激酶抑制剂，抑制 RET (WT)、RET (V804M) 、RET (G810R)的IC50分别为 14.0 nM、24.1 nM、530.7 nM，具有抗肿瘤活性。摘自专利文献 WO2018071447A1 中的化合物 Example 163。

Selpercatinib is a tyrosine kinase inhibitor with antineoplastic properties(IC50 of 14.0 nM, 24.1 nM, and 530.7 nM for RET (WT), RET (V804M) , and RET (G810R), respectively)

2152628-33-4

C29H31N7O3

525.613

LOXO-292

DMSO:8.33 mg/mL (15.85 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years