MD-224是一种基于蛋白水解靶向嵌合体（PROTAC）概念的高效、高效的Mdm2降解剂，是一类新型抗癌剂。

MD-224 is a highly potent and efficacious MDM2 degrader based on the proteolysistargeting chimera (PROTAC) concept,and as a new class of anticancer agent.

MD-224 effectively induces rapid degradation of MDM2 at concentrations<1 nM in human leukemia cells.?It achieves an IC50 value of 1.5 nM in inhibition of growth of RS4;11 cells and also low nanomolar IC50 values in a panel of leukemia cell lines.

MD-224 achieves complete and durable tumor regression in vivo in the RS4;11 xenograft tumor model in mice at well-tolerated dose schedules.

2136247-12-4

C48H43Cl2FN6O6

889.81

DMSO:150 mg/mL (168.58 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years