NSC 66811 是一种Mdm2-p53抑制剂，其结合到 Mdm2 的Ki值为 120 nM。

NSC 66811is a novel inhibitor of the murine double minute 2 (MDM2)-p53 interaction. It binds to MDM2 with a Ki of 120 nM and activates p53 in cancer cells with a mechanism of action consistent with targeting the MDM2-p53 interaction.

Due to the functional activation of p53, NSC 66811 (0, 5, 10, 20 μM) dose-dependently induces the accumulation of p53, MDM2, and p21cip1/waf.

6964-62-1

C23H20N2O

340.426

DMSO:99 mg/mL (290.81 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years