HS1371是一种新型高效的ATP竞争性受体相互作用蛋白激酶 3 抑制剂，IC50为 20.8?nM。

HS-1371 is a novel kinase inhibitor of receptor-interacting protein kinase 3 (RIP3) with an IC50 of 20.8 nM.

HS-1371 directly binds to RIP3 in an ATP-competitive and time-independent manner, providing a mechanism of action.?Moreover, the compound inhibited TNF-induced necroptosis but did not inhibit TNF-induced apoptosis, indicating that this novel inhibitor has a specific inhibitory effect on RIP3-mediated necroptosis via the suppression of RIP3 kinase activity.?HS-1371 could serve as a potential preventive or therapeutic agent for diseases involving RIP3 hyperactivation.

2158197-70-5

C24H24N4O

384.483

DMSO:16.67 mg/mL (43.36 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years