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Gartanin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Gartanin图片
CAS NO:33390-42-0
包装与价格:
包装价格(元)
5 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
藤黄苷
1,3,5,8-四羟基-2,4-双(3-甲基-2-丁烯基)-9H-氧杂蒽-9-酮
产品介绍
Gartanin 是山竹果中的一种天然黄酮,具有抗氧化、抗真菌、抗炎、神经保护和抗肿瘤活性。它能够诱导人脑胶质瘤细胞的细胞周期阻滞和自噬,抑制其迁移。

产品描述

Gartanin is an androgen receptor degradation enhancer, it is also a potential neuroprotective agent against glutamate-induced oxidative injury partially through increasing Nrf-2-independed HO-1 and AMPK/SIRT1/PGC-1α±signaling pathways.

体外活性

The interaction of Gartanin with the ligand-binding domain was characterized using a fluorescence polarization cell-free assay and cell-based FRET assay. Western blot analysis identified modulation of ER stress markers (BiP, PERK, IRE1, and CHOP) along with androgen receptor degradation. A computation simulation was performed to identify possible orientations of Gartanin with the ligand-binding domain. Utilizing a cell-free and cell-based FRET assays Gartanin was found to interact with the ligand-binding domain through a solely antagonist interaction. Interestingly, inhibition of CHOP, a critical component of the ER stress pathway, was observed to stabilize AR[1]

Cas No.

33390-42-0

分子式

C23H24O6

分子量

396.43

别名

藤黄苷;1,3,5,8-四羟基-2,4-双(3-甲基-2-丁烯基)-9H-氧杂蒽-9-酮

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years