AZD4205 是一种选择性JAK1抑制剂，IC50值为 73 nM。

AZD4205 is a selective JAK1 inhibitor (IC50: 73 nM) and weakly inhibits JAK2/JAK3 (IC50: >14.7, >30 μM).

AZD4205 significantly inhibits STAT3 phosphorylation in NCI-H 1975 cells (IC50: 161 nM).

AZD4205 (12.5 mg/kg BID (twice daily), 25 m/kg BID, or 50 mg/kg BID, p.o.) alone has increasing antitumor effects, and enhances the antitumor activity of osimertinib, compared to treatment with osimertinib alone in mice bearing NCI-H1975 cells.

2091134-68-6

C25H31N9O2

489.57

AZD4205

DMSO:250 mg/mL (510.65 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years