Valproic acid是一种 HDAC 抑制剂，可抑制HDAC1的活性，同时可诱导HDAC2的降解。它激活Notch1信号并抑制小细胞肺癌细胞的增殖。它可研究癫痫、双相情感障碍和偏头痛等。

Valproic Acid is a branched chain fatty acid which potentially enhances central GABAergic neurotransmission and inhibits Na+ channels. Currently, the various molecular mechanisms of action of Valproic Acid have not been completely elucidated. Valproic Acid has been reported to be a potent inhibitor of histone deacetylases (HDACs) in vitro. Valproic Acid is also noted to relieve HDAC-dependent transcriptional repression and causes the hyperacetylation of histones in cultured cells. Additionally, Valproic Acid is reported to activate Wnt-dependent gene expression and to mimic trichostatin A (sc-3511) in the inhibition of histone deacetylase.

Xylazine can be used for sedation, anesthesia, muscle relaxation, and analgesia in animals such as horses, cattle and other non-human mammals. Xylazine has recently emerged as a recreational drug, especially in Puerto Rico [1]. Administration of xylazine (0.17 mg/kg of body weight, diluted to a 10-ml volume, using 0.9% NaCl) induced approximately 2.5 hours of local analgesia without apparent side effects. Higher doses of xylazine caused mild hind limb ataxia. Administration of lidocaine-induced a similar duration of analgesia, with severe hind limb ataxia (100% incidence) [2].

99-66-1

C8H16O2

144.214

VPA;Depakine;Sodium valproate;2-Propylvaleric Acid;丙戊酸;2-Propylpentanoic Acid

H2O:1 mg/mL (6.93 mM),Need ultrasonic and warming
DMSO:100 mg/mL (693.43 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years