CB-103 是口服具有活性的蛋白相互作用抑制剂,靶向NOTCH转录复合体,具有抗肿瘤作用。
产品描述
CB-103 is a orally active inhibitor of notch signaling pathway, with anti-tumor activity.
体外活性
CB-103 has shown the ability to block NOTCH signaling in human T cell acute lymphoblastic leukemia cancer cell lines, and?exhibits anti-tumor efficacy in GSI resistant T-ALL cell lines[2].
体内活性
CB-103?inhibits growth of GSI/Mab resistant triple negative breast cancer, and?exhibits anti-tumor activity in xenograft models of human T-ALL and mouse mammary tumors[3].
Cas No.
218457-67-1
分子式
C15H18N2O
分子量
242.32
储存和溶解度
DMSO:230 mg/mL (949.16 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years