IMR-1A 是 IMR-1 的酸代谢物。IMR-1A 是Notch抑制剂，IC50=0.5 μM。IMR-1A相对于 IMR-1 的效力提高了 50 倍。

IMR-1A is the metabolite of IMR-1 which is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L.

IMR-1 prevents the recruitment of Maml1 to the NTC on chromatin, inhibits Notch target gene transcription, and dramatically inhibits tumor growth. A decrease in colony formation of Notch-dependent cell lines is observed upon treatment with IMR-1 when compared with the control (DMSO).

The reference for intraperitoneal injection is 15 mg/kg. IMR-1 inhibits Notch-dependent somite development in zebrafish.

331862-41-0

C13H11NO5S2

325.35

DMSO:31 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years