LEQ506 是一种 Smo 抑制剂，对 hSmo 和 mSmo 的 IC50 分别为 2 nM 和 4 nM。

LEQ506 is a Smo inhibitor with IC50s of 2 nM and 4 nM for hSmo and mSmo, respectively.

LEQ506 consistently decreases Gli1 mRNA by about 70 to 80%. LEQ506 shows a tendency to preferentially inhibit Gli1 rather than Ptch1 mRNA. LEQ506 (at 1%) is also an efficacious compound with an inhibition of 80 to 90% for Gli1 and 60 to 70% for Ptch1[1]. LEQ506 inhibits Hedgehog signaling in a human cell line (HEPM) as measured by the amount of Gli mRNA with an IC50 ~6-fold lower than that of Compound 2[2].

1204975-42-7

C25H32N6O

432.56

NVP-LEQ506

DMSO:100 mg/mL (231.18 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years