Fz7-21 是一种 Frizzled 7 (FZD 7) 受体的肽抑制剂，能够选择性的与FZD7 CRD亚类结合。它还阻断了WNT3A介导的β-CATenin在小鼠L细胞中的稳定作用。它对外源性WNT3A刺激和转染WNT3A或WNT1的HEK293细胞Wnt/β-CATenin信号传导有损伤。

Fz7-21 is a peptide antagonist of FZD7 . It antagonises WNT3A-induced Wnt-β-catenin signalling in HEK293 expressing FZD7. Fz7-21 impairs Wnt/β-catenin signaling in HEK293 cells stimulated with exogenous WNT3A (IC50=100 nM) or transfected with a construct expressing WNT3A or WNT1. Fz7-21 also blocks WNT3A-mediated stabilization of β-catenin in mouse L cells (IC50=50 nM).

2247635-23-8

C83H114N18O23S2

1796.05

(Ac)-LPSDDLEFWCHVMY-NH2

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years