Wnt agonist 1 是细胞通透性Wnt信号激活剂，能够诱导 TCF 依赖的转录活性(EC50>700 nM)。

Wnt agonist 1 (BML-284) is a potent, selective and , cell-permeable Wnt signaling activator.

Wnt agonist 1 does not inhibit the activity of GSK-3β, and may be a useful tool in the study of physiological processes that involve the Wnt pathway. [1]

In a Xenopus model, Wnt agonist 1 (10 μM) mimics the effects of Wnt at the whole-organism level, and affects Xenopus embryonic head specification. [1]

853220-52-7

C19H18N4O3·HCl

386.83

Wnt agonist 1

H2O:<1 mgml
Ethanol:<1 mgml
DMSO:77 mg/mL (199.05 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years