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I3MT-3
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
I3MT-3图片
CAS NO:459420-09-8
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
500 mg电议

产品名称
HMPSNE
产品介绍
I3MT-3 是一种有效的、具有细胞膜渗透性的、选择性的 3-巯基丙酮酸硫转移酶 (3MST)的抑制剂,IC50值为2.7 μM,对其他硫化氢/磺胺制硫酶没有活性。它靶向位于 3MST 活性位点的过硫半胱氨酸残基。

产品描述

I3MT-3 (HMPSNE) is a potent, selective and cell membrane permeability inhibitor of 3-mercaptopyruvate sulfur transferase (3MST), which targets the persulfated cysteine residues located at the active site of 3MST.

体外活性

I3MT-3 shows a dose-dependent inhibition of 3-MST activity from CT26 homogenates, which contain the murine form of the enzyme. The IC50 of HMPSNE for murine 3-MST is calculated as 2.3 μM with a cozncentration-dependent decrease of AzMC fluorescence[1].I3MT-3 (0-300 μM; 48 hours) inhibits CT26 cells proliferate with increasing concentrations of I3MT-3. Confluence of cells treated with HMPSNE is recorded each hour for 48 h by the IncuCyte method[2].

Cas No.

459420-09-8

分子式

C17H14N2O2S

分子量

310.37

别名

HMPSNE

储存和溶解度

DMSO:120mg/mL (386.64mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years