XL413 是一种口服生物可利用的细胞分裂周期 7 同源物 (CDC7) 激酶抑制剂，具有潜在的抗肿瘤活性，IC50值为 3.4 nM。它对 pMCM 的EC50值为 118 nM，对 CK2 和 Pim1 的IC50值分别为 215 和 42 nM。

XL-413 is an orally bioavailable cell division cycle 7 homolog (CDC7) kinase inhibitor with potential antineoplastic activity. XL-413 binds to and inhibits the activity of CDC7, which may result in the inhibition of DNA replication and mitosis, the induction of tumor cell apoptosis, and the inhibition of tumor cell proliferation in CDC7-overexpressing tumor cells.

1169558-38-6

C14H12ClN3O2

289.72

DMSO:Soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years