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HOKU-81
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
HOKU-81图片
CAS NO:58020-43-2
包装:25mg
市场价:2552元

产品介绍
HOKU-81 (4-Hydroxytulobuterol) 是 Tulobuterol 的代谢物之一。
Cas No.58020-43-2
别名4-羟基妥洛特罗,4-Hydroxytulobuterol;HOKU 81;HOKU81
化学名4-[2-(tert-butylamino)-1-hydroxyethyl]-3-chlorophenol
Canonical SMILESCC(C)(C)NCC(C1=C(C=C(C=C1)O)Cl)O
分子式C12H18ClNO2
分子量243.73
溶解度Soluble in DMSO
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

HOKU-81, a new bronchodilator, is one of the metabolites of tulobuterol. IC50 Value: Target: Adrenergic ReceptorEffects of HOKU-81 on isolated trachea and atria of guinea pigs were compared with those of various bronchodilators. HOKU-81 appears to be a potent and selective beta 2-stimulant with a slight inotropic action. HOKU-81 was approximately 8 times more potent than tulobuterol, approximately twice as potent as salbutamol, and approximately as potent as isoprenaline in relaxing effect on the isolated tracheal smooth muscle preparation of guinea pigs. This effect of HOKU-81 seems to be due to direct action on the adrenergic beta-receptor.

References:
[1]. Kubo S, Matsubara I, Yamazaki M et al. Pharmacological studies of 1-(2-chloro-4-hydroxyphenyl)-2-t-butylaminoethanol (HOKU-81), a new bronchodilator. 1st Communication: Bronchodilator and cardiovascular actions. Arzneimittelforschung. 1980;30(8):1272-8.
[2]. Gomi Y, Shirahase H, Funato H. Effects of 1-(2-chloro-4-hydroxyphenyl)-t-butylaminoethanol (HOKU-81), a new bronchodilator, on isolated trachea and atria of guinea pig. Jpn J Pharmacol. 1979 Aug;29(4):515-24.