Chroman 1 是高效的的ROCK选择性抑制剂，对 ROCK2 (IC50=1 pM) 的抑制作用强于 ROCK1 (IC50=52 pM) 。它对MRCK也有抑制作用，IC50为 150 nM。

Chroman 1 is a potent inhibitor of ROCK1 (IC50 = 52 pM) and ROCK2 (IC50 = 1 pM).

Chroman 1 also shows inhibitory activities against MRCK (IC50: 150 nM). However, it has no effect on PKA (IC50, >20000 nM) or AKT1 (IC50, >20000 nM).

1273579-40-0

C24H28N4O4

436.5

DMSO:50 mg/mL (114.55 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years