Y-39983 hydrochloride是一种选择性的Rho-associated coiled coil-forming protein kinase (ROCK)抑制剂。

Y-39983 hydrochloride is a selective Rho-associated coiled coil-forming protein kinase (ROCK) inhibitor.

In rabbits, topical administration of Y-39983 significantly increased conventional outflow by 65.5%, followed by significant, dose-dependent reduction in IOP. Maximum IOP reduction was 13.2 ± 0.6 mm Hg (mean ± SE) at 0.1% Y-39983 in rabbits. In monkeys, at 3 hours after topical administration of 0.05% Y-39983, maximum reduction of IOP was 2.5 ± 0.8 mm Hg. No serious side effects were observed in ocular tissues except sporadic punctate subconjunctival hemorrhage during long-term topical administration of Y-39983 four times a day (at 2-hour intervals) in rabbits or monkeys. However, punctate subconjunctival hemorrhage was not observed with administration twice daily (at a 6-hour interval) or three times a day (at 5-hour intervals)[1].

471843-75-1

C16H17ClN4O

316.79

盐酸Y-39983;Y-33075 HCl;SNJ-1656;RKI-983;Y-39983 HCl

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years